Reducing skeletal complications and bone pain with intravenous ibandronate for metastatic bone disease
نویسندگان
چکیده
منابع مشابه
Intravenous ibandronate reduces the incidence of skeletal complications in patients with breast cancer and bone metastases.
BACKGROUND This phase III study compared the efficacy of the new potent bisphosphonate, ibandronate, with placebo as intravenous (i.v.) therapy in metastatic bone disease due to breast cancer. PATIENTS AND METHODS A total of 466 patients were randomised to receive placebo (n = 158), or 2 mg (n = 154) or 6 mg (n = 154) ibandronate every 3-4 weeks for up to 2 years. The primary efficacy paramet...
متن کاملIbandronate to treat skeletal-related events and bone pain in metastatic bone disease or multiple myeloma: a meta-analysis of randomised clinical trials
OBJECTIVE Randomised controlled trials (RCTs) have given contradictory results about the efficacy and safety of ibandronate in treating metastatic bone disease (MBD) or multiple myeloma. This review meta-analysed the literature to gain a more comprehensive picture. DESIGN Systematic review and meta-analysis of ibandronate compared with placebo or zoledronate. DATA SOURCES PubMed, EMBASE and...
متن کاملRole of bisphosphonates for the management of skeletal complications and bone pain from skeletal metastases.
Bone metastases are common in patients with advanced-stage cancer; they can lead to skeletal complications (ie, pathologic fractures, spinal cord compression, tumor-induced hypercalcemia, and severe bone pain) that often require orthopedic surgery or palliative radiation therapy and negatively affect quality of life. The primary role of bisphosphonates for the management of bone metastases in p...
متن کاملIbandronate: The loading dose concept in the treatment of metastatic bone pain.
BACKGROUND/AIM Severe bone pain is experienced by 60-80% of patients with metastatic bone disease, and has a profound impact on quality of life. Therefore, effective pain relief is an important goal in managing metastatic bone disease. Orthopedic surgeons are often challenged with patients presenting with newly diagnosed bone metastases and severe and disabling bone pain. It is important to pro...
متن کاملMetastatic bone disease
OBJECTIVES Guidelines for the management of patients with metastatic bone disease (MBD) have been available to the orthopaedic community for more than a decade, with little improvement in service provision to this increasingly large patient group. Improvements in adjuvant and neo-adjuvant treatments have increased both the number and overall survival of patients living with MBD. As a consequenc...
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ژورنال
عنوان ژورنال: European Journal of Cancer Supplements
سال: 2004
ISSN: 1359-6349
DOI: 10.1016/j.ejcsup.2004.01.002